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Aurora magazine

The blog about the prenatal genetic of latest generation

Too much fat in pregnancy marks the metabolism

Taking weight during pregnancy is normal, within certain limits. Numerous studies show that eating too much in pregnancy affects the health of both the mother and the baby. But researchers at the University of California went further. In fact, their study analyzes the long-term effects of a too high-fat pregnant diet. From what emerged, a diet unregulated during gestation reprograms the metabolism even after delivery. It therefore makes it easier to gain weight in subsequent years.

A team of researchers analyzed the state of health of a group of pregnant guinea pigs. Scholars fed part of the guinea pigs in a normal way and partly with very fat foods. The guinea pigs of the second group obviously took a lot of weight, but they lost almost immediately after giving birth. Despite this, the effects of high-fat nutrition were seen months after delivery.

The guinea pigs have resumed eating normally after losing weight. Even with a normal diet, three months after giving birth they began to gain weight. Nine months after delivery, they weighed about twice as high as the average. According to scholars, the high fat diet carried out during pregnancy has slowed the metabolism even at the end of gestation. This made it easier to accumulate fat mass and excess weight.

What has been discovered for mice is also applicable to humans. A too fat diet during pregnancy could increase the risk of obesity in years of childbirth. Even losing weight immediately, in fact, would remain the changes made to the metabolism with a diet so uneven. For further confirmation, however, an analysis will also be conducted on human beings.

Source: medicalxpress.com

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Does excess cannabis reduce fertility?

According to a study led by Professor Susan Murphy at Duke University, too much cannabis could reduce male fertility. THC could in fact condition the DNA methylation of spermatozoa. The result? Less healthy gametes and less able to fertilize an oocyte, triggering the embryo development process. In addition, cannabis could significantly reduce sperm count. For this reason, the teacher advises to cut the consumption at least six months before starting to try to have a child.

The use of cannabis immediately before and during pregnancy is at the center of a large number of studies. To date, it is unclear how the substance affects embryonic development. In this case, however, at the center of the study there was the impact on male fertility rather than on the embryo itself. Researchers have in fact analyzed the effects of consumption on animal models and on 24 human volunteers.

Scholars compared the sperm of those who used cannabis regularly, those who had stopped for six months and those who had used it no more than 10 times in their lives. The semen of men with high levels of THC in the urine showed much more genetic anomalies than others. The genes involved would have an important impact on fertility and, it is thought, also on the possible development of an embryo.

The next step will be to gather a much larger group of volunteers. In this way there will be more material to evaluate the real effects of the substance on male fertility.

Source: medicaldialogues.in

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Noonan syndrome: what it is and how it manifests itself

Noonan syndrome is a genetic disease with an incidence of 1 case per 1000-2500 newborns. It includes a wide variety of clinical manifestations, but the most common are congenital heart disease. In addition to these, which affect almost 70% of patients, other symptoms are:

  • short;
  • lowering of the eyelids;
  • spaced eyes;
  • big ears;
  • chest malformation;
  • cognitive deficits;
  • lack of descent of the testes in the scrotum.

Diagnosis takes place starting from the observation of the above symptoms. An analysis of family history follows, with the confirmation of a genetic investigation. Although some of the genes involved are known, in some cases the genetic cause remains unknown. Furthermore, the clinical variability of the disease makes the diagnosis much more difficult. Nevertheless, if there are family cases, prenatal diagnosis can be used.

Noolan syndrome is a hereditary and sporadic genetic disease. In the first case, transmission occurs in an autosomal dominant manner: to develop the disease, a copy of the altered gene is sufficient. In 50% of cases, the affected gene is PTPN11; in all other cases, mutations affect the KRAS, NRAS, RAF1, BRAF and SOS1 genes. However, only 75% of patients show identifiable and clear genetic variants.

For the moment there is no resolution therapy for Noolan syndrome. Several studies are underway on drugs that could inhibit the activity of mutated enzymes. Cardiac lesions are treatable with surgery and in some cases hormone therapy is recommended. If followed appropriately, children can reach adulthood without problems.

Source: telethon.it

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Does bisphenol A, contained in the plastic, make it sterile?

The decline in fertility and true infertility is an increasingly common problem in the world. More and more studies prove that much of the blame lies with lifestyle. Smoking, a sedentary lifestyle, lack of sleep and unhealthy eating reduce the rate of fertility. Part of the infertility cases could however also be linked to bisphenol A (BPA), a substance contained in most of the plastic containers.

BPA is a molecule used for the synthesis of some plastics, such as those used for water bottles. With the increase in urbanization, plastic containers have also increased. As a result, we are increasingly in contact with the bisphenol A content of food and soap packaging. The problem is that it seems that this molecule has serious consequences on fertility, especially on the male one.

A good number of studies suggest that BPA reduces sperm motility, thus affecting fertility. Approximately 15% of the increase in male infertility is thought to be related to high BPA levels. This, together with the consumption of more and more foods rich in fats and oxidants, could explain at least a slice of the cases of infertility. The phenomenon is evident above all in the big cities like Bangalore, in India.

Bancalore suffers from a veritable epidemic of male and female infertility. In the last 10 years, cases of infertility have increased by about 30%, many of them without apparent reason. In parallel, there has been an increase in the use of plastic packaging and bottles, especially in the food sector. It seems strange that the two phenomena are not in any way related. This is why more and more doctors are pointing at bisphenol A, also in the light of various international studies.

Bisphenol A would act similarly to estrogen, affecting the endocrine system. This could translate into less sperm motility and ovulation problems. To have certain answers, however, further studies will be needed.

Source: deccanherald.com

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