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Why choose AURORA


A Offer your patients a better service compared to invasive prenatal screening tests. AURORA is a safe, reliable, quick and early test. In fact, it differs from invasive prenatal diagnostic tests (amniocentesis, chorionic villus sampling, cordocentesis) for its reliability (test sensitivity higher than 99.9%  for trisomy 21 and trisomy 18) and for its non-invasiveness, ensuring absolute absence of miscarriage risks.


B  Offer your patients a  better service, also compared to other  non-invasive prenatal screening tests:

  1. Other tests conduct biochemical investigations on maternal blood or ultrasound measurements, while the AURORA test directly analyzes the fetal DNA circulating in maternal blood, with a reliability rate of 99.9% for the main trisomies.
    Eng img dati01Example of technical performance for one of the AURORA test procedures compared to alternative tests.

  2. Other non-invasive prenatal tests show high error frequencies (rates of false positives, cases in which the test detects a chromosomal abnormality that is not actually present in the fetus).
    Eng img dati02Example of technical performance for one of the AURORA test procedures compared to alternative tests.

  3. Easy-to-read results with two alternatives: aneuploidy "detected" or aneuploidy "not detected".

C Offer a leading technological test  with anexcellent service

Technological innovation

The tests are performed in California, USA, at the Illumina Inc. labs, using the cutting edge technology of massive parallel sequencing (MPS) of the entire human genome. It has the following advantages:

Advantages of the Aurora test

1

Higher sensitivity

(>99.9%) and reduction of false negatives (>0.1%)**

2

Higher reliability

(>99.7%) and reduction of false positives (>0.3%)**

3

Better performance

Repetition rate < 1 in 1,000 patient

4

CLEAR results

Aneuploidy “detected” or “undetected” instead of risk rates

Test accuracy

Reference table
ChromosomeSensitivity %False negatives %Specificity %False positives
Trisomy 21 99.14 0.86 99.94 <0.1
Trisomy 18 98.31 1.69 99.90 0.1
Trisomy 13 98.15 1.85 99.95 <0.1
Monosomy x 95 5 99.0 1
xxx-xxy-xyy Rare aneuploidies, unmeasurable accuracy
Sex determination - xx 97.6 2.4 99.2 0.8
Sex determination - xy 99.1 0.9 98.9 1.1
Trisomy 9 Rare aneuploidies, unmeasurable accuracy
Trisomy 16 Rare aneuploidies, unmeasurable accuracy
Microdeletions Rare aneuploidies, unmeasurable accuracy

Legend:
Sensitivity  = power of the test, expressed in percentage terms, to identify the presence of a aneuploidy

Specificity = power of the test, expressed in percentage terms, to exclude those who have not developed an aneuploidy

False negatives = cases in which the test does not detect a chromosomal abnormality present in the fetus

False positives = cases in which the test does not detect a chromosomal abnormality which is not actually present in the fetus

*Bianchi DW et al., N Eng J Med 2014 Feb 27; 370(9):799-808

**Values for trisomy 21. For other abnormalities refer to accuracy of the test table

Better performance

AURORA has the lowest rate of repeat testing than other tests on fetal DNA

eng img genitori 06 3

Excellence of the Service

The AURORA service simplifies gynaecologists’ tasks compared to any other test:

  • maternal blood sampling can be done, at the request of the patient, at her domicile;
  • medical reports accompanied by a technica l report by a qualified geneticist;
  • the kit packaging and shipment procedures are handled by Sorgente Genetica, thus relieving the gynaecologist’s office/medical centre of the performance of such activity;
  • dedicated customer support and daily shipments.