Aurora magazine

The anti-inflammatory drug against certolizumab pegol arthritis is also safe during pregnancy. In fact, it stops in front of the placental barrier and can not reach the baby. The discovery was made by a team led by Dr. Xavier Mariette of the Paris Bicêtre Hospital.

The study involved 16 pregnant women between 1st and 30th week of gestation. Women were taking 200 milligrams of certolizumab pegol every 2 weeks and 400 every 4 weeks. The reasons for pharmacology therapy ranged from rheumatoid arthritis to arthritic psoriasis, including Crohn's disease. All patients continued with therapy up to 35 days before the expected date of delivery.

Once the children were born, the researchers used microplates to analyze their blood. Physicians have sampled between the 4th and 8th week of life. In the case of 14 of them, they also managed to get a blood sample at birth. They checked if there was any evidence of the drug taken by the mothers in the children's body.

The data did not show significant levels of certolizumab pegol in 13 of the 14 samples harvested at birth. None of the samples collected in the following weeks showed traces of the drug. There were also no antibodies that would suggest a reaction to the drug. This demonstrates that the therapy does not affect the child's health as the drug clings to the placental barrier.

Source: medicalnewstoday.com

Researchers at the Karolinska Institutet have shown how sperm proteins attack the oval barrier. The study reveals how the sperm recognizes the surface of the oval and penetrate it, previously unclear. All this has been documented with 3D images of the fertilization process. This will help to better understand the reproduction mechanics in mammals.

Luca Jovine's team used data from the European Synchrotron Radiation Facility (ESRF), obtained by X-ray crystallography. The researchers thus showed the interaction between sperm and ZP2 proteins. The molecule contains repeated sequences that play a key role in recognizing gametes. Among other things, it is very similar to a protein with similar functions, VERL, which is present in molluscs.

Taking advantage of the similarity between ZP2 and VERL, the researchers used the aliotids as models. They are very simple molluscs, which facilitated the observation of VERL protein at work. Scholars have thus studied how the protein binds to lysine, a protein present in sperm. The process opens a hole in the oval barrier, allowing the sperm to enter.

Source: ki.se

Paracetamol in pregnancy interferes with the development of the fetus. In particular, the drug would have negative consequences on male sexual behavior. It is the discovery of the team of David Møbjerg Kristensen of the University of Copenhagen. For the time being, the studies have been limited to the observation of animal models, but they still raise an important problem.

Paracetamol is one of the most used painkillers and doctors consider it safe for pregnant women as well. The study in question and the previous ones, always conducted on animal models, raise a question about it. Other studies have shown that fetal exposure to the drug may alter testosterone production. This study analyzes possible changes in sexual behavior.

The researchers administered paracetamol to pregnant guinea pigs. The dosages used were equivalent to those recommended for human puerperers. They then followed the male males from birth to adulthood. Cavities exposed to paracetamol in the fetal phase were found to be incapable of clumping like the other. According to the study, the drug has interfered with the development of male characteristics, with adulthood in adulthood.

he reasons for abnormal sexual behavior may be low in testosterone levels. Testosterone plays a key role in male sexual development. Mice exposed to paracetamol had less testosterone, were less aggressive and less active on the sexual level. In addition, the cerebral area that controls the sex drive was smaller.

Discovery could change the guidelines for taking the drug in pregnancy. According to the authors, paracetamol should be taken only in extreme cases.

Source: quotidianosanita.it

Food tastes are an early discovery, which even goes back to life in the mother's womb. It was highlighted by a team of experts during the Round Table "Food in the First 1000 Days of Life". The event was held in Naples during the congress of the Italian Society of Pediatrics.

According to pediatricians, the baby's relationship with food begins even before giving birth. It is important for the future mom to control pregnancy. The passage of nutrients through the placenta affects not only the baby's development, but also its taste. Unhealthy eating can have negative consequences both physically and in the face of future eating habits. During pregnancy it is advisable to undergo prenatal screening tests, such as fetal DNA test. These examinations calculate the probability percentage for which the fetus may be affected by chromosomal abnormalities.

After breastfeeding, it is advisable to choose breastfeeding wherever possible. Breastfeeding should go as far as possible, even up to the year of life. Breastfeeding is in fact essential for proper physical and psychological development. If the mother is unable to breastfeed, it is good to make sure the baby is taking omega3.

At the time of weaning any tastes already present in the child emerge. The best way to guide them to a healthy, balanced diet is to contact your pediatrician. He will be able to advise the foods to be introduced, in the right manner and time.

Source: ansa.it